9.12.07

Increasing Melanin in Skin

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Increasing Melanin in Skin - The role of melanin in the skin fotoprotektora as shown in numerous works [4-6, 8, 10]. At the same time, data on the quantity of contents in various skin fototipov inadequate [2, 3, 7]. In examining the absorbing properties of epidermis spectroscopy method observed maximum values of light waves to penetrate the skin in the range of 270 to 600 nm [5]. For skin melanin absorption maximum value is within the range of ultraviolet light B (UFV), with a wavelength of 290-320 nm [6]. According to some researchers, wave length 290-320 nm pass through a layer of epidermis lid on 30-60%, and across the epidermis at 10-35% [5]. Most expressed erythema and skin pigmentation raises UFV-izluchenie Increasing Melanin in Skin.

Fotoprotektsiya effected by the Absorption and acquisitions. This will affect both the process and density distribution among melanosom keratinotsitov. Large, vysokomelanizirovannye melanosomy black people can absorb much more solar energy than smaller, less dense, poor melanin melanosomy svetlokozhih [8, 10]. The wave length of 300 nm penetrating only by 10-15% through the epidermis of persons with bright skin, compared to 2-5% for the skin Negroids [6]. Differences in the ability to skip a single layer of skin epidermis for UFV from different racial groups have been noted. Thus, oxidized layer of bright people with skin has not fotoprotektiven far less than the cornea layer Negroids. At the same time epidermis for people with darker skin fotoprotektsii received the greatest significance for all wavelengths Increasing Melanin in Skin. Thus, we can assume that Negroids filtering sunlight occurs mainly in the basal layer of epidermis by melanin, a keratinotsity top layer of the epidermis remain unprotected exposure. In contrast, people with darker skin absorption principal place of the svetlokozhih is oxidized layer, which absorbed up to 50% of sunlight. Similar results were observed for the UFA, and for the UFV Increasing Melanin in Skin.

Gilchrest, Barbara A. (Brookline, MA, US)

Increasing Melanin in Skin - Details

Melanin is a special pigment that gives the skin and hair its natural color. It makes the skin tanned, but also produces unwanted freckles, birthmarks and other colored marks on the body.

Increasing Melanin in Skin - More Details

With humans melanin forms in special sea-star shaped cells called melanocytes in the basal layer of epidermis and then transforms into granules where pigments are combined with protein. Melanocytes inject melanin grains into the cells of the upper skin layer (cortical layer of the hair and the iris of the eye) and determine their color.

Increasing Melanin in Skin - Doctors view

Doctors from time to time state that tea, coffee, chocolate and cacao are harmful for our health. However, it is no good to give up these products once and for all as they contain melanin that is essential for the human organism. Also prunes, bilberry or dark grapes are good protection against cancer, sunburns and influence of radiation.
Dose UV light which causes minimal erythema eyes visible through 24 h after exposure, or call biodozoy eritemnoy minimum dose (MED). Biodozu expressed in minutes or in the quantity of energy per unit area, that is, mDzh/sm2 (UFV), or Dzh/sm2 (UFA). This figure depends on the individual and skin phototype, the thickness of epidermis, the availability vysypany pathological effects of radiation in the ground. According to research different authors, MED healthy skin from Negroids at 10-33 times higher than for those with bright skin and Increasing Melanin in Skin.

It is known that Increasing Melanin in Skin requires individual therapeutic treatment, the choice of which is based on determining the MED for a particular patient. These doses are well understood and generally accepted methods chosen for phototherapy, and for black and white UFV length of 308 nm with standard therapy scheme lacks [7, 11].

Our studies demonstrate strong dependence of skin phototype MED patient. Dose determined to carry out Increasing Melanin in Skin patients and psoriasis. Increasing Melanin in Skin to use the installation of laser ML-308 (Center physical instrument, Troitsk), generating a range of ultraviolet light pulses with a wavelength 308 nm. Registration MED conducted visually and through tips "Mexameter MX 18", part of the apparatus of "C utometer 580 MPA" (CK electronic GmbH, Germany).

Increasing Melanin in Skin new optical diagnostic method designed to measure levels of Increasing Melanin in Skin and melanin in the skin section of the analyte. Its advantage over other methods are Increasing Melanin in Skin and instant results. During their passage through the skin luminous flux absorbed by hemoglobin and melanin, collagen fibers dispersed derma, and then repeats its path in the opposite direction through the layers of derma and epidermis. In the visible spectral band composition reflected light skin is defined mainly melanin and hemoglobin number. It melanin absorbs light over a wide range of wavelengths, from ultraviolet to infrared. Hemoglobin has the same characteristic absorption bands in the spectral ranges of about 420 and 545-575 nm.

Gordon, Philip R. (Philadelphia, PA, US)

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Increasing Melanin in Skin and Increasing MelaninIncreasing Melanin in Skin and Melanin in the Hair


Increasing Melanin in Skin - Good Hair

Having a good hair day doesn’t just happen by chance. It happens when taking care of your hair becomes just as important as taking care of your skin. But what do you do when your hair has been damaged by every day styling, and chemical processing, dyeing or perming? Is there any solution for fly-away hair, dullness and faded color?

Increasing Melanin in Skin - Science view

The color of hair is determined by the amount of melanin in the cortical layer. Dark hair has a lot of pigment while fair hair has fewer granules that are of smaller size. Diffusive or non-granulated melanin makes the hair red. Hair, like any other part of the body, requires essentials nutrients for growth and survival.

Increasing Melanin in Skin and Melanin in SkinIncreasing Melanin in Skin and Increase Tanning Melanin


Increasing Melanin in Skin - Good Skin

When summer looms, many people start considering the best way to get that sun-bronzed glow — turning to self-tanners, tanning booths, a stretch in the sun, or a combination of these.

Increasing Melanin in Skin - Science view

But before you go into a tanning booth — spend a few minutes finding out about your skin and sun exposure. These facts can help you get the look you want without stressing your skin.

Increasing Melanin in Skin - More Details

Melanin is the body's way of protecting skin from burning. Darker-skinned people tan more deeply than lighter-skinned people because their melanocytes produce more melanin. But just because a person doesn't burn does not mean that he or she is also protected against skin cancer and other problems.

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Increasing Melanin in Skin - People view

In our studies conducted attended 50 patients psoriasis and 30 patients with Vitiligo II, III and IV fototipami (FT) on the classification of skin Fitzpatrick. All patients in the history of the increased guidance was not Increasing Melanin in Skin.

Increasing Melanin in Skin (definition MED) served on the inner surface of the skin forearm eksimernogo using ultraviolet laser radiation source with a wavelength of 308 nm. Through svetoprovod exposure to the field of oxygen flow pulses with a maximum energy in a single pulse 7 mJ, the length of 30 ns and frequency of 70 Hz. Area light-staining was 3.14 cm2. Thus, the density of radiation in a single pulse-2.23 mDzh/sm2. When Increasing Melanin in Skin density UFV-izlucheniya escalated from 111.5 to 557.5 mDzh/sm2 to step 111.5 mDzh/sm2. Data Increasing Melanin in Skin skin in sections of the Increasing Melanin in Skin evaluated after 24 h, 7 and 10 days (Figure 1).

In visual evaluation for patients with MED II FT skin upon exposure UFV-izlucheniya recorded with a density 111,5-223 mDzh/sm2, for the III and IV Increasing Melanin in Skin - 223-557,5 mDzh/sm2. At the skin of patients with IV FT not always been able to see the pigmentation and erythema, but after 2-3 days in the field fotoprob showing slight peeling. According to the literature, MED for broadband UFV is between 20 mDzh/sm2 (MED for I FT skin) to 57 mDzh/sm2 (MED for IV FT) [9]. Thus, the results showed a higher threshold for monochrome MED UFV. Therefore, in comparison with broadband UFV only 1 seance can significantly increase the radiation dose without risk of burns side effects and Increasing Melanin in Skin.

Increasing Melanin in Skin - More Details

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Increasing Melanin in Skin - Science view

It is known that when the impact of broadband UFV erythema developed through 12-24 h and completely disappears through 72-120 h. We have studied the dynamics of increasing the level of melanin and reduce erythema at the venues of Increasing Melanin in Skin depending on the density of black and white UFV-izlucheniya within 10 days (see Fig. 1, a, b, c). The maximum level for all Increasing Melanin in Skin density radiation reaches within 24 hours Exhibition 1-2 MED leads to a small increase in the level of melanin and a minimum level of increase as erythema through 24 h, and at 7-10 days. Exhibition 2-3 MED raises expressed increase in the level of erythema after 24 h, and after 7-10 days in the midst of reducing rates erythema registered a moderate increase in the concentration of melanin. Exhibition 4-5 MED is even more significant increase in the level of background slight erythema at the lower melanin within 24 h, but after 7-10 days in the midst of reducing Increasing Melanin in Skin reaction there has been a considerable increase in the level of melanin and Increasing Melanin in Skin.

Furthermore, we have conducted measurements constitutional melanin levels on the inner surface of the forearms (free from tanning) in patients with a variety of skin FT (Fig.2). For patients with the values I FT melanin levels have always been less than 100 units for FT II ranged from 90 to 135, for the FT III comprised 130-200 and IV FT-from 200 to 260 units.

As shown by the results of the experiment for black and white UFV MED with a wavelength of 308 nm is for the various FT skin from 111.5 to 557.5 mDzh/sm2 and exceeds MED for broadband UFV in 5-6 times. Comprehensive assessment MED, constitutional level of melanin and FT patient on a scale Increasing Melanin in Skin maximizes exactly match the initials therapeutic doses in all methods of phototherapy.

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